![](/CAS/GIF/13195-64-7.gif)
Diisopropyl malonate synthesis
- Product Name:Diisopropyl malonate
- CAS Number:13195-64-7
- Molecular formula:C9H16O4
- Molecular Weight:188.22
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![Cyanoacetic acid](/CAS/20180808/GIF/372-09-8.gif)
372-09-8
350 suppliers
$20.00/25g
![Isopropyl alcohol](/CAS/GIF/67-63-0.gif)
67-63-0
1554 suppliers
$16.00/25ML
![Diisopropyl malonate](/CAS/GIF/13195-64-7.gif)
13195-64-7
281 suppliers
$5.00/10g
Yield:-
Reaction Conditions:
Stage #1:cyanoacetic acid;isopropyl alcohol at 90; for 3 h;
Stage #2:ethanol with hydrogenchloride in water at 50; for 5 h;
Steps:
3 Example 3 A method for preparing diisopropyl malonate:
1) Esterification The 70wt% concentration of cyanoacetic acid was mixed with the corresponding isopropanol to carry out the esterification reaction. The temperature was 90° C. and the temperature was maintained for 3 hours. The esterification reaction was completed; the molar ratio of cyanoacetic acid:isopropanol was 1:1.1.2) Dehydration waterAfter the reaction, the material is kept at a temperature of 60°C and subjected to normal pressure and vacuum distillation to remove excess alcohol and water in the material and control the moisture content of the alcohol end point material to be ≤ 3%;3) Alcoholysis esterificationThe dealcoholated material was maintained at a temperature of 50°C, then a hydrogen chloride-isopropanol solution was added and reacted at 50°C for 5 hours; the molar ratio of cyanoacetic acid:hydrogen chloride:isopropanol was 1:1.6:1.9. 4) Crude ester separationAfter the alcoholysis was completed, the material was cooled to 40°C, ammonia water was adjusted to pH 7.2, and the alcohol was degassed at regular pressure.Afterwards, the temperature was lowered to 34° C., water-soluble salt was added, and the ester layer and the salt water layer were separated after standing. The ester layer was distilled to obtain the malonate ester product.
References:
Weifang Binhai Petrochemical Co., Ltd.;Dou Rongtan;Lin Xiaopeng;Sun Zhenmin;Li Jianming;Song Shuai;Wang Tingwei CN107540543, 2018, A Location in patent:Paragraph 0059-0068
![Malonic acid](/CAS/GIF/141-82-2.gif)
141-82-2
739 suppliers
$5.00/25g
![Isopropyl alcohol](/CAS/GIF/67-63-0.gif)
67-63-0
1554 suppliers
$16.00/25ML
![Diisopropyl malonate](/CAS/GIF/13195-64-7.gif)
13195-64-7
281 suppliers
$5.00/10g
![2-Bromopropane](/CAS/GIF/75-26-3.gif)
75-26-3
449 suppliers
$10.00/10g
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
736 suppliers
$5.00/25g
![Diisopropyl malonate](/CAS/GIF/13195-64-7.gif)
13195-64-7
281 suppliers
$5.00/10g
![Isopropyl alcohol](/CAS/GIF/67-63-0.gif)
67-63-0
1554 suppliers
$16.00/25ML
![2-Cyanoacetamide](/CAS/GIF/107-91-5.gif)
107-91-5
540 suppliers
$5.00/10g
![Diisopropyl malonate](/CAS/GIF/13195-64-7.gif)
13195-64-7
281 suppliers
$5.00/10g
![Isopropyl alcohol](/CAS/GIF/67-63-0.gif)
67-63-0
1554 suppliers
$16.00/25ML
![Malonyl chloride](/CAS/GIF/1663-67-8.gif)
1663-67-8
212 suppliers
$36.79/5g
![Diisopropyl malonate](/CAS/GIF/13195-64-7.gif)
13195-64-7
281 suppliers
$5.00/10g