ChemicalBook CAS DataBase List 2-AMINODIETHYLMALONATE

2-AMINODIETHYLMALONATE synthesis

8synthesis methods

Product Name:2-AMINODIETHYLMALONATE
CAS Number:6829-40-9
Molecular formula:C7H13NO4
Molecular Weight:175.18

13433-00-6 Synthesis

13433-00-6
466 suppliers
$9.00/1g

6829-40-9
95 suppliers
$45.00/5 g

Yield:6829-40-9 99%

Reaction Conditions:

with sodium hydrogencarbonate in dichloromethane;water

Steps:

1.1
A saturated aqueous solution of sodium hydrogencarbonate (100 ml) and hydrochloric acid salt of diethyl 2-aminomalonate (10.0 g; 47.3 mmol) were added to dichloromethane (100 ml) and stirred. The aqueous layer was extracted with dichloromethane and the organic phase was washed with brine. The organic phase was separated and dried over anhydrous magnesium sulfate. After filtration, the filtrate was collected and the solvent was removed under reduced pressure to give diethyl 2-aminomalonate [3] (8.16 g; 46.6 mmol; yield 99%) as a colorless oil. ¹H-NMR (400 MHz, CDCl₃): δ 4.31 (5H, m), 1.89 (3H, s), 1.31-1.26 (6H, m)

References:

MBR Co., Ltd.;Kato, Nobuo EP2196460, 2010, A1 Location in patent:Page/Page column 6

FullText