![](/CAS/GIF/1068-90-2.gif)
Diethyl acetamidomalonate synthesis
- Product Name:Diethyl acetamidomalonate
- CAS Number:1068-90-2
- Molecular formula:C9H15NO5
- Molecular Weight:217.22
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
733 suppliers
$5.00/25g
![1,4-Dioxane](/CAS/GIF/123-91-1.gif)
123-91-1
664 suppliers
$16.00/25g
![Diethyl acetamidomalonate](/CAS/GIF/1068-90-2.gif)
1068-90-2
536 suppliers
$5.00/25g
Yield:1068-90-2 86%
Reaction Conditions:
with acetic acid;sodium nitrite in water
Steps:
5 Example 5
Example 5 A mixture of 1,4-dioxane, acetic acid and water, obtained from a previous reaction mixture by taking a low-boiling cut, was metered into a stirred mixture of 320.4 g (2.0 mol) of diethyl malonate and 160 g (2.3 mol) of sodium nitrite (technical grade), maintained at 35° C. 12.0 g of water were then metered in and 166 g (207. mol) of acetic acid (96%) were added dropwise over 2 hours. The mixture was allowed to continue reacting for 2 hours at 40° C. and was worked up as described in Example 4. There remained 425 g of light yellow oil, which, after catalytic hydrogenation and recrystallization of the crude product, gave diethyl acetaminomalonate at a yield of 86% of theory, based on the diethyl malonate employed, and with a purity of >99.8 FID area percent.
References:
Huels Aktiengesellschaft US5861533, 1999, A
![Diethyl aminomalonate hydrochloride](/CAS/GIF/13433-00-6.gif)
13433-00-6
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![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
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$17.92/100G
![Diethyl acetamidomalonate](/CAS/GIF/1068-90-2.gif)
1068-90-2
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$5.00/25g
![Diethyl aminomalonate hydrochloride](/CAS/GIF/13433-00-6.gif)
13433-00-6
463 suppliers
$9.00/1g
![Acetic anhydride](/CAS/20180808/GIF/108-24-7.gif)
108-24-7
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$14.00/250ML
![Diethyl acetamidomalonate](/CAS/GIF/1068-90-2.gif)
1068-90-2
536 suppliers
$5.00/25g
![Diethyl Isonitrosomalonate](/CAS/GIF/6829-41-0.gif)
6829-41-0
34 suppliers
$199.00/500mg
![Diethyl acetamidomalonate](/CAS/GIF/1068-90-2.gif)
1068-90-2
536 suppliers
$5.00/25g