TERT-BUTYL ETHYL MALONATE synthesis
- Product Name:TERT-BUTYL ETHYL MALONATE
- CAS Number:32864-38-3
- Molecular formula:C9H16O4
- Molecular Weight:188.22
1071-46-1
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75-65-0
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32864-38-3
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$8.00/5g
Yield:32864-38-3 66%
Reaction Conditions:
with dicyclohexyl-carbodiimide in acetonitrile for 2 h;
Steps:
Synthesis of Malonic acid tert-butyl ester ethyl ester
Synthesis of Malonic acid tert-butyl ester ethyl ester tert-butanol (2.8 mL, 37.8 mmol) was added to a stirred solution of malonic acid monoethyl ester (5 g, 37.8 mmol) in acetonitrile (45 mL). DCC (8.58 g, 41.6 mmol) dissolved in acetonitrile (5 mL) was added dropwise with stirring over a period of 2 hours. The reaction mixture was filtered and the filtrate was concentrated to afford 4.72 g (66%) of malonic acid tert-butyl ester ethyl ester. LCMS: 189.11 (M+1)+ 93.4%, 1H NMR: (CDCl3): δ 4.2 (q, 2H), 3.3 (s, 2H), 1.4 (s, 9H), 1.3 (t, 3H).
References:
FOREST LABORATORIES HOLDINGS LIMITED US2009/239848, 2009, A1 Location in patent:Page/Page column 29
36239-09-5
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32864-38-3
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1071-46-1
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115-11-7
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32864-38-3
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626-35-7
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32864-38-3
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