ChemicalBook CAS DataBase List TERT-BUTYL ETHYL MALONATE

TERT-BUTYL ETHYL MALONATE synthesis

8synthesis methods

Product Name:TERT-BUTYL ETHYL MALONATE
CAS Number:32864-38-3
Molecular formula:C9H16O4
Molecular Weight:188.22

1071-46-1 Synthesis

1071-46-1
289 suppliers
$5.00/1g

75-65-0 Synthesis

75-65-0
752 suppliers
$10.00/10ml

32864-38-3
219 suppliers
$8.00/5g

Yield:32864-38-3 66%

Reaction Conditions:

with dicyclohexyl-carbodiimide in acetonitrile for 2 h;

Steps:

Synthesis of Malonic acid tert-butyl ester ethyl ester
Synthesis of Malonic acid tert-butyl ester ethyl ester tert-butanol (2.8 mL, 37.8 mmol) was added to a stirred solution of malonic acid monoethyl ester (5 g, 37.8 mmol) in acetonitrile (45 mL). DCC (8.58 g, 41.6 mmol) dissolved in acetonitrile (5 mL) was added dropwise with stirring over a period of 2 hours. The reaction mixture was filtered and the filtrate was concentrated to afford 4.72 g (66%) of malonic acid tert-butyl ester ethyl ester. LCMS: 189.11 (M+1)⁺ 93.4%, ¹H NMR: (CDCl₃): δ 4.2 (q, 2H), 3.3 (s, 2H), 1.4 (s, 9H), 1.3 (t, 3H).

References:

FOREST LABORATORIES HOLDINGS LIMITED US2009/239848, 2009, A1 Location in patent:Page/Page column 29

FullText

36239-09-5 Synthesis