7-methoxy-2,3-dihydro-1,4-benzodioxine-6-carbaldehyde(SALTDATA: FREE) synthesis

6synthesis methods

Product Name:7-methoxy-2,3-dihydro-1,4-benzodioxine-6-carbaldehyde(SALTDATA: FREE)
CAS Number:116757-66-5
Molecular formula:C10H10O4
Molecular Weight:194.18

7-hydroxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde

116757-65-4
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7-methoxy-2,3-dihydro-1,4-benzodioxine-6-carbaldehyde(SALTDATA: FREE)

116757-66-5
16 suppliers
$182.00/500mg

Yield:116757-66-5 69 %

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20;

Steps:

16 [Example 16] Preparationof 7-methoxy-1,4-benzodioxane-6-carbaldehyde (7)

Compound (2) (0.62 g, 3.4 mmol) was dissolved in DMF (5 mL) and potassium carbonate ( 0.57 g, 4.1 mmol) and methyl iodide (0.71 g, 4.1 mmol) were added, and the mixture was stirred overnight at room temperature.The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with an aqueous sodium oxide solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Compound (7) (0.46 g, 69%) was obtained.

References:

JP2022/144914,2022,A Location in patent:Paragraph 0089-0090