ChemicalBook CAS DataBase List Cyclohexanecarboxylic acid, 1-fluoro-, methyl ester (9CI)

Cyclohexanecarboxylic acid, 1-fluoro-, methyl ester (9CI) synthesis

6synthesis methods

Product Name:Cyclohexanecarboxylic acid, 1-fluoro-, methyl ester (9CI)
CAS Number:117169-32-1
Molecular formula:C8H13FO2
Molecular Weight:160.19

500899-64-9 Synthesis

1-Oxaspiro[2.5]octane-2-carbonitrile, (-)-

500899-64-9
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Cyclohexanecarboxylic acid, 1-fluoro-, methyl ester (9CI)

117169-32-1
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 86 percent / 70percent HF / CH₂Cl₂; pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 1 h
2: 74 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / 0 °C
3: 59 percent / Jones reagent / acetone / 0 °C
4: 79 percent / diethyl ether / 5 °C

References:

Mongelli;Animati;D'Alessio;Zuliani;Gandolfi [Synthesis,1988,# 4,p. 310 - 313]