methyl 2-methyl-2-(4-(2-(tosyloxy)ethyl)phenyl)propanoate synthesis

Yield:1181267-30-0 91%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 1 h;

Steps:

6
Example 6: Preparation of2-methyl-2-{4-[2-(toluene-4-sulfonyloxy)-ethyl]-phenyl}-propionic acid methylester; In a reaction vessel, 2-[4-(2-hydroxy-ethyl)-phenyl]-2-methyl-propionic acid methylester(2g) prepared in the Examples 1-3, triethylamine(1.1g), p-toluenesulfonylchloride(1.9g) and dichloromethane(20ml_) were introduced, and the mixture was reacted at room temperature for 1 hour. Distilled water(50mL) was added thereto, and the mixture was stirred to separate layers. The separated organic layer was dehydrated with Na₂SO-_I, and then condensed by filtration to obtain 2-methyl-2-{4-[2-(toluene-4-sulfonyloxy)-ethyl]-phenyl}-propionic acid methylester(3.0g, yield 91%).¹H-NMR, 400MHz, CDCI₃, ppm : δ 1.57(s, 6H), 2.44(s, 3H), 2.93(t, 2H), 3.65(s, 3H), 4.18(t, 2H), 7.05-7.07(d, 2H), 7.19-7.21(d, 2H), 7.27-7.30(d, 2H), 7.69(d, 2H)

References:

YUHAN CORPORATION WO2009/102155, 2009, A2 Location in patent:Page/Page column 15

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