(2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester synthesis
- Product Name:(2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester
- CAS Number:1186637-29-5
- Molecular formula:C12H16BrNO2
- Molecular Weight:286.16
24424-99-5
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53078-85-6
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1186637-29-5
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$60.00/100mg
Yield:1186637-29-5 98%
Reaction Conditions:
Stage #1: 2-bromo-5-methylanilinewith sodium hydride in tetrahydrofuran; for 1 h;Reflux;Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;
Stage #3: with sodium hydride in tetrahydrofuran;Inert atmosphere;Reflux;
References:
Yamaoka, Yousuke;Yoshida, Takahiro;Shinozaki, Makiko;Yamada, Ken-Ichi;Takasu, Kiyosei [Journal of Organic Chemistry,2015,vol. 80,# 2,p. 957 - 964]