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ChemicalBook CAS DataBase List (2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester

(2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester synthesis

1synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
824 suppliers
$13.50/25G

53078-85-6 Synthesis
2-Bromo-5-methylbenzenamine

53078-85-6
193 suppliers
$6.00/1g

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Yield:1186637-29-5 98%

Reaction Conditions:

Stage #1: 2-bromo-5-methylanilinewith sodium hydride in tetrahydrofuran; for 1 h;Reflux;Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;
Stage #3: with sodium hydride in tetrahydrofuran;Inert atmosphere;Reflux;

References:

Yamaoka, Yousuke;Yoshida, Takahiro;Shinozaki, Makiko;Yamada, Ken-Ichi;Takasu, Kiyosei [Journal of Organic Chemistry,2015,vol. 80,# 2,p. 957 - 964]

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