![](/CAS/GIF/53078-85-6.gif)
2-Bromo-5-methylbenzenamine synthesis
- Product Name:2-Bromo-5-methylbenzenamine
- CAS Number:53078-85-6
- Molecular formula:C7H8BrN
- Molecular Weight:186.05
![4-Bromo-3-nitrotoluene](/CAS/GIF/5326-34-1.gif)
5326-34-1
247 suppliers
$6.00/5g
![2-Bromo-5-methylbenzenamine](/CAS/GIF/53078-85-6.gif)
53078-85-6
193 suppliers
$6.00/1g
Yield:53078-85-6 99%
Reaction Conditions:
with formic acid;triethylamine;platinum on carbon at 100; for 12.3333 h;
Steps:
1 Synthesis of 2-bromo-5-methylaniline References:
Saitoh, Hiroshi;Mizuno, Tsuyoshi;Tsuchiya, Naoki US2003/191325, 2003, A1 Location in patent:Page/Page column 8
Production Example 1 Synthesis of 2-bromo-5-methylaniline 4-Bromo-3-nitrotoluene (60.35 g, 279 mmol), 5% by weight platinum carbon (1.09 g, 0.28 mmol) and triethylamine (112.93 g, 1116 mmol) were stirred under heating at 100° C., to which formic acid (99%) (42.39 g, 921 mmol) was added dropwise over 20 minutes. After stirring for 12 hours, it was brought back to room temperature, and then 100 ml of ethyl acetate and 100 ml of water were added thereto. After stirring well, it was filtered through celite to remove platinum carbon. By further adding 200 ml of ethyl acetate and 100 ml of water, it was extracted, the organic phase was washed with water (300 ml*3 times), and dried on magnesium sulfate. The solvent was evaporated to obtain 2-bromo-5-methylaniline (51.30 g, 276 mmol). The yield was 99%. 1H-NMR (270 MHz, CDCl3) δ(ppm): 7.260 (1H, d), 6.583 (1h
![4-Bromo-3-nitrotoluene](/CAS/GIF/5326-34-1.gif)
5326-34-1
247 suppliers
$6.00/5g
![Iron](/CAS/GIF/7439-89-6.gif)
7439-89-6
420 suppliers
$10.00/25g
![2-Bromo-5-methylbenzenamine](/CAS/GIF/53078-85-6.gif)
53078-85-6
193 suppliers
$6.00/1g
![4-Methyl-2-nitroaniline](/CAS/20180808/GIF/89-62-3.gif)
89-62-3
219 suppliers
$13.00/25g
![2-Bromo-5-methylbenzenamine](/CAS/GIF/53078-85-6.gif)
53078-85-6
193 suppliers
$6.00/1g
![4-Bromo-2-nitrotoluene](/CAS/GIF/60956-26-5.gif)
60956-26-5
290 suppliers
$8.00/10g
![2-Bromo-5-methylbenzenamine](/CAS/GIF/53078-85-6.gif)
53078-85-6
193 suppliers
$6.00/1g
![m-Toluidine](/CAS/GIF/108-44-1.gif)
108-44-1
365 suppliers
$9.00/1g
![2-Bromo-5-methylbenzenamine](/CAS/GIF/53078-85-6.gif)
53078-85-6
193 suppliers
$6.00/1g