ChemicalBook CAS DataBase List 4-(3-chlorophenylamino)-7-methoxyquinazolin-6-yl acetate

4-(3-chlorophenylamino)-7-methoxyquinazolin-6-yl acetate synthesis

8synthesis methods

Product Name:4-(3-chlorophenylamino)-7-methoxyquinazolin-6-yl acetate
CAS Number:1187223-25-1
Molecular formula:C17H14ClN3O3
Molecular Weight:343.76

108-42-9 Synthesis

108-42-9
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230955-75-6 Synthesis

230955-75-6
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$11.00/250mg

4-(3-chlorophenylamino)-7-methoxyquinazolin-6-yl acetate

1187223-25-1
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Yield:1187223-25-1 66%

Reaction Conditions:

in isopropanol; for 4 h;Reflux;

Steps:

1.1. General procedure forthe preparation of compounds 3a-3d

General procedure: A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (1, 10 mmol) and appropriate substituted anilines (12 mmol) in isopropanol (80 mL) was stirred at reflux for 4 h. The mixture was cooled to room temperature and the resultant precipitate was collected by filtration and washed with isopropanol. The solid was dried to give compounds 3a-3d.

References:

Peng, Fan-Wei;Wu, Ting-Ting;Ren, Zi-Wei;Xue, Jia-Yu;Shi, Lei [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 22,p. 5137 - 5141] Location in patent:supporting information

179688-52-9 Synthesis

6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

179688-52-9
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References

179688-53-0 Synthesis

3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

179688-53-0
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References

6,7-Dimethoxy-3,4-dihydroquinazoline-4-one

13794-72-4
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$8.00/1g

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93-07-2 Synthesis

93-07-2
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$5.00/5g

1187223-25-1
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References