ChemicalBook CAS DataBase List 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one synthesis

8synthesis methods

Product Name:6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
CAS Number:179688-52-9
Molecular formula:C9H8N2O3
Molecular Weight:192.17

6,7-Dimethoxy-3,4-dihydroquinazoline-4-one

13794-72-4
285 suppliers
$8.00/1g

6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

179688-52-9
235 suppliers
$6.00/1g

Yield:179688-52-9 94%

Reaction Conditions:

with methanesulfonic acid;L-methionine at 100; for 22 h;

Steps:

1.1-2
( 1 -2) 6-hydroxy-7-methoxyquinazolin-4(3H)-one; 3.06 g of the compound obtained in (1-1) was diluted with 20 mi of methanesulfonic acid. 2.66 g of /--methionine was added to the resulting solution and stirred at 100 ^°C for 22 hours. Ice was added to the reaction mixture and neutralized with 40% aqueous sodium hydroxide to induce the crystallization of the product. The solid was filtered under a reduced pressure, washed with water, and air-dried to obtain the title compound (2.67 g, 94%).¹H-NMR (300MHz, DMSO-d₆) δ 11.94 (s, IH), 9.81 (s, IH), 7.92 (_?, IH), 7.39 (s, IH), 7.11 (s, IH), 3.91 (s, 3H).

References:

HANMI PHARM. CO., LTD. WO2008/150118, 2008, A2 Location in patent:Page/Page column 21

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