![](/CAS/GIF/184475-71-6.gif)
O-Desmorpholinopropyl Gefitinib synthesis
- Product Name:O-Desmorpholinopropyl Gefitinib
- CAS Number:184475-71-6
- Molecular formula:C15H11ClFN3O2
- Molecular Weight:319.72
![4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate](/CAS/GIF/788136-89-0.gif)
788136-89-0
107 suppliers
$6.00/250mg
![O-Desmorpholinopropyl Gefitinib](/CAS/GIF/184475-71-6.gif)
184475-71-6
218 suppliers
$5.00/250mg
Yield:184475-71-6 95.3%
Reaction Conditions:
with sodium methoxide in methanol; for 3 h;Reflux;
Steps:
1.5 5) Preparation of 4- (3-chloro-4-fluoro) phenylamino-6-hydroxy-7-methoxyquinazoline (6)
To the reaction vessel was added 4- (3-chloro-4-fluoro) phenylamino-6-carbethoxy-7-methoxyquinazoline (3.61 g,10mmol), dissolved in 30mL methanol, added sodium methoxide (2.7g, 50mmol), stirred evenly, heated to reflux, reaction 3hour. After completion of the reaction, the solid was removed by filtration, and the solid was cooled to give 4- (3-chloro-4-fluoro) phenylamino-6-hydroxy-7-methoxy Ylquinazoline was obtained in a yield of 95.3%.
References:
CN106045980,2016,A Location in patent:Paragraph 0027; 0028; 0029
![N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(phenylmethoxy)-4-quinazolinamine](/CAS/GIF/913819-12-2.gif)
913819-12-2
13 suppliers
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![O-Desmorpholinopropyl Gefitinib](/CAS/GIF/184475-71-6.gif)
184475-71-6
218 suppliers
$5.00/250mg
![3-Chloro-4-fluoroaniline](/CAS/GIF/367-21-5.gif)
367-21-5
504 suppliers
$5.00/25g
![3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate](/CAS/GIF/179688-53-0.gif)
179688-53-0
273 suppliers
$6.00/1g
![O-Desmorpholinopropyl Gefitinib](/CAS/GIF/184475-71-6.gif)
184475-71-6
218 suppliers
$5.00/250mg
![3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate](/CAS/GIF/179688-53-0.gif)
179688-53-0
273 suppliers
$6.00/1g
![O-Desmorpholinopropyl Gefitinib](/CAS/GIF/184475-71-6.gif)
184475-71-6
218 suppliers
$5.00/250mg
![6,7-Dimethoxy-3,4-dihydroquinazoline-4-one](/CAS/GIF/13794-72-4.gif)
13794-72-4
285 suppliers
$8.00/1g
![O-Desmorpholinopropyl Gefitinib](/CAS/GIF/184475-71-6.gif)
184475-71-6
218 suppliers
$5.00/250mg