1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-1-(phenylsulfonyl)- synthesis

3synthesis methods

Product Name:1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-1-(phenylsulfonyl)-
CAS Number:1196507-56-8
Molecular formula:C13H8ClIN2O2S
Molecular Weight:418.64

4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE

1015610-31-7
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$42.00/250mg

98-09-9
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1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-1-(phenylsulfonyl)-

1196507-56-8
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Yield:1196507-56-8 98%

Reaction Conditions:

Stage #1: 4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridinewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0; for 0.333333 h;
Stage #2: benzenesulfonyl chloride in N,N-dimethyl-formamide;mineral oil at 20; for 2 h;

Steps:

12.C

[00335] Step C: NaH (0.960 g, 24.0 mmol, 60% dispersion in mineral oil) at 0⁰C was added to 4-chloro-5-iodo-lH-pyrrolo[2,3-b]pyridine (5.57 g, 20.0 mmol) in dimethylformamide ("DMF"; 40 mL) and stirred at 0⁰C for 20 minutes. Benzenesulfonyl chloride (2.82 mL, 22.0 mmol) was added, and the reaction was stirred at room temperature for 2 hours. Water (200 mL) was added and stirred for 10 minutes. The solid formed was collected by filtration, washed with ether, and dried to give 4-chloro-5-iodo-l-(phenylsulfonyl)-lH-pyrrolo[2,3-b]pyridine (8.20 g, 98% yield).

References:

WO2009/140320,2009,A1 Location in patent:Page/Page column 98-99

1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-

651744-48-8
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References

1015609-83-2 Synthesis

4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

1015609-83-2
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References