ChemicalBook CAS DataBase List (2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+%

(2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+% synthesis

8synthesis methods

Product Name:(2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+%
CAS Number:1203507-02-1
Molecular formula:C19H20N2S
Molecular Weight:308.44

136-95-8 Synthesis

136-95-8
394 suppliers
$7.00/25g

(2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+%

1203507-02-1
41 suppliers
$45.00/10mg

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: diethyl ether / 20 °C / Molecular sieve
2.1: 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / dichloromethane; water / 72 h / 0 °C
3.1: sodium tetrahydroborate; methanol / 5 h / 0 °C
4.1: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 40 °C
5.1: triethylamine; methanesulfonyl chloride / 1.6 h / 5 - 20 °C / Inert atmosphere
5.2: 1.5 h / Reflux

References:

Frías, María;Carrasco, Ana Cristina;Fraile, Alberto;Alemán, José [Chemistry - A European Journal,2018,vol. 24,# 13,p. 3117 - 3121]