ChemicalBook CAS DataBase List Tert-Butyl 2-Amino-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate(WX141382)

Tert-Butyl 2-Amino-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate(WX141382) synthesis

10synthesis methods

Product Name:Tert-Butyl 2-Amino-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate(WX141382)
CAS Number:1209487-56-8
Molecular formula:C11H18N4O2
Molecular Weight:238.29

1209488-61-8 Synthesis

Tert-Butyl 2-(((Benzyloxy)Carbonyl)Amino)-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate

1209488-61-8
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Tert-Butyl 2-Amino-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate(WX141382)

1209487-56-8
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$90.00/5mg

Yield:1209487-56-8 100%

Reaction Conditions:

with hydrogen;20% palladium(II) hydroxide on carbon in tetrahydrofuran;methanol;water at 20; for 4 h;

Steps:

2-1.8

Step 8 To a solution of Compound I-158 (508.7 mg, 1.366 mmol) in tetrahydrofuran:methanol (1:1, 7.0 mL), 20% palladium hydroxide-carbon (50% of water content, 100 mg) was added. The solution was then stirred under hydrogen atmosphere at room temperature for 4 hours. The reaction solution was filtered, and then the filtrate was concentrated in vacuo to yield Compound I-55 (1.52 g, 100%). LC/MS (Method D): 0.92 min, [M+H]⁺ = 239 ¹H-NMR (CDCl₃) δ: 5.41 (1H, s), 4.53 (2H, s), 3.95 (2H, t, J = 5.3 Hz), 3.84 (2H, t, J = 5.3 Hz), 1.48 (9H, s).

References:

EP2327704,2011,A1 Location in patent:Page/Page column 53-54