ChemicalBook CAS DataBase List 6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester synthesis

5synthesis methods

Product Name:6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester
CAS Number:1211586-09-2
Molecular formula:C11H20N2O2
Molecular Weight:212.29

1181816-12-5 Synthesis

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

1181816-12-5
183 suppliers
$9.00/100mg

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

1211586-09-2
118 suppliers
$46.00/100mg

Yield:-

Steps:

Multi-step reaction with 3 steps
1: methanol; sodium tetrahydroborate / 1 h / 0 - 25 °C / Inert atmosphere
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 0 - 25 °C / Inert atmosphere
3: hydrazine hydrate / ethanol / 1.5 h / 25 °C

References:

Xuanzhu Pharma Co., Ltd.;WU, Frank EP3281942, 2018, A1

1239320-12-7 Synthesis