2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one synthesis

5synthesis methods

Product Name:2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
CAS Number:1221186-56-6
Molecular formula:C9H6BrN3OS
Molecular Weight:284.13

ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

1221186-55-5
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2-broMo-4,6-dihydro-4-Methyl-5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

1221186-56-6
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Yield:1221186-56-6 400 mg

Reaction Conditions:

with hydrazine hydrate in 2-methoxy-ethanol at 110; for 2 h;

Steps:

4.E Step E. Synthesis of 2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin- 5(6H)-one

To a mixture of ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b] pyrrole-5- carboxylate (550 mg, 1.7 mmol) in 2-methoxyethanol (20 mL) was added hydrazine hydrate (2 mL, 98% w/w). The mixture was stirred at 110 °C for 2 hr and cooled down. The precipitate was collected by filtration and washed with water to give 400 mg of 2-bromo-4- methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d] pyridazin-5(6H)-one. LC-MS (ESI): m/z 284 (M+H)⁺.

References:

WO2020/167976,2020,A1 Location in patent:Page/Page column 78-79

4701-17-1 Synthesis