tert-butyl 3-(2-methyl-2H-tetrazol-5-yl)pyrrolidine-1-carboxylate synthesis

1synthesis methods

Product Name:tert-butyl 3-(2-methyl-2H-tetrazol-5-yl)pyrrolidine-1-carboxylate
CAS Number:1225218-83-6
Molecular formula:C11H19N5O2
Molecular Weight:253.3

tert-butyl 3-(2H-tetrazol-5-yl)pyrrolidine-1-carboxylate

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tert-butyl 3-(2-methyl-2H-tetrazol-5-yl)pyrrolidine-1-carboxylate

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tert-butyl 3-(1-methyl-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate

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Yield:-

Reaction Conditions:

with potassium carbonate in acetonitrile; for 3 h;Reflux;

Steps:

B

Iodomethane (37.0 μL, 0.600 mmol) was added to a stirred solution of i-17a (120 mg, 0.500 mmol) and potassium carbonate (97.0 mg, 0.700 mmol) in acetonitrile (5.00 mL), and the resulting mixture was heated to reflux. After 3 h, the reaction mixture was cooled to rt, filtered and concentrated in vacuo. The crude residue was dissolved in DCM, and the organics were washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound, i-17b, and regioisomer, i-17c. mlz (ES) 254 (MH)^H .

References:

WO2010/51245,2010,A1 Location in patent:Page/Page column 51-52