2-(3-trifluoroMethylphenyl)iMidazole[4,5f][1,10]phenanthroline synthesis

Yield:1233850-90-2 82.3%

Reaction Conditions:

with ammonium acetate;acetic acid at 100; for 0.333333 h;Microwave irradiation;

Steps:

3.3.1. Synthesis of 1

General procedure: A mixture of 1,10-phenanthroline-5,6-dione (315.06 mg, 1.50 mmol), 3-nitrobenzaldehyde(339.81 mg, 2.25 mmol), ammonium acetate (4 g, 51.9 mmol) and glacial acetic acid (20 mL) washeated at 100 C for 20 min under microwave irradiation. Then, 20 mL of water was added and the pH value was adjusted to 7.0 at room temperature. The solution was filtered and dried in vacuum toobtain a yellow precipitate, which was collected and washed with water and small amounts of ethanol.The crude product dissolved in ethanol was purified by filtration on silicagel column (60-100 mesh).

References:

Li, Li;Cao, Jie-Qiong;Liu, Hui-Min;Wu, Qiong;Pan, Qiu-Hui;Zeng, Zhi-Ping;Lan, Yu-Tao;Li, Yu-Mei;Mei, Wen-Jie;Wang, Xi-Cheng;Zheng, Wen-Jie [Molecules,2017,vol. 22,# 5,art. no. 829]