BETA-OXO-2-PYRIDINEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER synthesis

6synthesis methods

Product Name:BETA-OXO-2-PYRIDINEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
CAS Number:123440-85-7
Molecular formula:C12H15NO3
Molecular Weight:221.255

2524-52-9 Synthesis

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BETA-OXO-2-PYRIDINEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

123440-85-7
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Yield:123440-85-7 90%

Reaction Conditions:

with sodium methylate in toluene at 60 - 80; for 5 h;

Steps:

1-3 Example 2

In a 1000-ml reaction kettle, 151 g of ethyl 2-picolinate, 60 g of sodium methoxide and 400 g of toluene were added, the temperature was raised to 60-80 ° C, 120 g of tert-butyl acetate was added dropwise, and the reaction was continued for 5 hours after completion of the drop. After cooling, 200 g of water was added, the liquid was separated, and excess ethyl acetate was removed to obtain 199 g of tert-butyl 2-pyridylacetoacetate with a yield of 90.0%. Used for the next reaction.

References:

CN110790700,2020,A Location in patent:Paragraph 0017-0018; 0020-0021; 0023-0024

2459-07-6 Synthesis