![](/CAS/GIF/123440-85-7.gif)
BETA-OXO-2-PYRIDINEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER synthesis
- Product Name:BETA-OXO-2-PYRIDINEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
- CAS Number:123440-85-7
- Molecular formula:C12H15NO3
- Molecular Weight:221.255
Yield:123440-85-7 90%
Reaction Conditions:
with sodium methylate in toluene at 60 - 80; for 5 h;
Steps:
1-3 Example 2
In a 1000-ml reaction kettle, 151 g of ethyl 2-picolinate, 60 g of sodium methoxide and 400 g of toluene were added, the temperature was raised to 60-80 ° C, 120 g of tert-butyl acetate was added dropwise, and the reaction was continued for 5 hours after completion of the drop. After cooling, 200 g of water was added, the liquid was separated, and excess ethyl acetate was removed to obtain 199 g of tert-butyl 2-pyridylacetoacetate with a yield of 90.0%. Used for the next reaction.
References:
CN110790700,2020,A Location in patent:Paragraph 0017-0018; 0020-0021; 0023-0024
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98-98-6
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![2-Cyanopyridine](/CAS/GIF/100-70-9.gif)
100-70-9
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123440-85-7
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