ChemicalBook CAS DataBase List 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- synthesis

1synthesis methods

Product Name:2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
CAS Number:1235318-89-4
Molecular formula:C12H12N6S
Molecular Weight:272.33

4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-amine

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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 100 °C
2: trifluoroacetic acid / 3 h / 90 °C

References:

Fujinaga, Masayuki;Yamasaki, Tomoteru;Nengaki, Nobuki;Ogawa, Masanao;Kumata, Katsushi;Shimoda, Yoko;Yui, Joji;Xie, Lin;Zhang, Yiding;Kawamura, Kazunori;Zhang, Ming-Rong [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 2,p. 370 - 374]

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