ChemicalBook >> CAS DataBase List >>2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- structure

CAS No.: 1235318-89-4

Chemical Name:: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

Synonyms: ADX88178;ADX-88178;ADX88178, >98%;ADX-88178;ADX 88178;ADX88178;4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine;2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine;Inhibitor,ADX 88178,mGluR,ADX88178,Metabotropic glutamate receptors,inhibit,ADX-88178

CBNumber:: CB62594800

Molecular Formula:: C12H12N6S

Molecular Weight:: 272.33

MDL Number:: MFCD21340285

MOL File:: 1235318-89-4.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

Request For Quotation

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Properties

storage temp.	Store at -20°C
solubility	DMSO:16.67(Max Conc. mg/mL);61.21(Max Conc. mM)

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-6961	ADX88178 99.60%	1235318-89-4	5mg	$110	2021-12-16	Buy
ChemScene	CS-6961	ADX88178 99.60%	1235318-89-4	10mg	$180	2021-12-16	Buy
DC Chemicals	DC10465	ADX-88178 >98%	1235318-89-4	1g	$1600	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-6961	5mg	$110	Buy
CS-6961	10mg	$180	Buy
DC10465	1g	$1600	Buy

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Chemical Properties,Uses,Production

Description

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.

target

ADX88178 is a metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- synthesis

Synthesis of 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- from 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-amine and 2-Bromo-4-methylpyrimidine

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Preparation Products And Raw materials

Raw materials

4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-amine 2-Bromo-4-methylpyrimidine

Preparation Products

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Suppliers

Global( 43)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4182	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shandong chuangyingchemical Co., Ltd.	58
Career Henan Chemica Co	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
MedChemexpress LLC	58
Shanghai JiYi Biotechnology Co. Ltd.	55
Shanghai Lollane Biological Technology Co.,Ltd.	55

2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine ADX88178 ADX-88178 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine ADX88178, >98% ADX-88178;ADX 88178;ADX88178 Inhibitor,ADX 88178,mGluR,ADX88178,Metabotropic glutamate receptors,inhibit,ADX-88178 1235318-89-4