ChemicalBook CAS DataBase List (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide

(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide synthesis

4synthesis methods

Product Name:(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide
CAS Number:1237261-65-2
Molecular formula:C23H24N2O3
Molecular Weight:376.45

1237261-60-7 Synthesis

(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-
phenylcyclopropanecarboxamide

1237261-60-7
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(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide

1237261-65-2
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Yield:1237261-65-2 85%

Reaction Conditions:

in dichloromethane; for 16 h;Reflux;Solvent;

Steps:

1.c c) Preparation of (1S,2R)-N,N-diethyl-2-phthalimidomethyl-1-phenylcyclopropylcarboxamide (Formula (II))

500 mL of a three-necked flask with mechanical agitation,Add the above(1S,2R)-N,N-diethyl-2-chloromethyl-1-phenylcyclopropylformamide dichloromethane and potassium phthalimide(40.75 g, 0.22 mol),And then refluxed for 16 hours, filtered and distilled at 50 ° C in dichloromethane (90 ml). Water (100 mL) was added and the distillation was continued. After drying without solvent, the residue was filtered to dryness to give pale yellow (1S,2R)-N,N-diethyl-2-phthalimidomethyl-1-phenylcyclopropylamide (63.95 g)Three-step total yield of 85% The purity was 98.5%.

References:

CN106083638,2016,A Location in patent:Paragraph 0065; 0070; 0071