2,3-dihydro-6-Methoxy-3-Methylene-1H-Isoindol-1-one synthesis
1synthesis methods
- Product Name:2,3-dihydro-6-Methoxy-3-Methylene-1H-Isoindol-1-one
- CAS Number:1239331-78-2
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
Yield:1239331-78-2 63%
Reaction Conditions:
Stage #1: trimethylsulfoxonium iodidewith sodium hydride in tetrahydrofuran;dimethyl sulfoxide at 0;
Stage #2: 2-formyl-5-methoxybenzonitrile in tetrahydrofuran;dimethyl sulfoxide;
References:
Kobayashi, Kazuhiro;Matsumoto, Kota;Nakamura, Daizo;Fukamachi, Shuhei;Konishi, Hisatoshi [Helvetica Chimica Acta,2010,vol. 93,# 6,p. 1048 - 1051] Location in patent:experimental part