1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine synthesis
1synthesis methods
- Product Name:1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine
- CAS Number:1240572-94-4
- Molecular formula:C11H10F3N3
- Molecular Weight:241.21
Yield:1240572-94-4 56%
Reaction Conditions:
with sodium carbonate in acetonitrile at 50; for 6 h;
Steps:
15.A
A suspension of 3-aminopyrazole (0.77 g, 9.27 mmol) and compound 10-8 (2.44 g, 10.21 mmol) in acetonitrile (40 mL) was treated with sodium carbonate (2.46 g, 23.18 mmol), and then the mixture was heated To 50°C,And kept at this temperature for 6h. Cool the mixture to 25°C,And filter out the insoluble matter. The supernatant was concentrated and purified by column chromatography (0% to 50% methanol/dichloromethane) to obtain pure product 8-9 (1.25g, 56%):
References:
CN113493442,2021,A Location in patent:Paragraph 0271-0274