1H-Indole-3-carboxylic acid, 5-bromo-1,2-dimethyl-, ethyl ester synthesis
- Product Name:1H-Indole-3-carboxylic acid, 5-bromo-1,2-dimethyl-, ethyl ester
- CAS Number:1245933-91-8
- Molecular formula:C13H14BrNO2
- Molecular Weight:296.16
Yield:1245933-91-8 92%
Reaction Conditions:
Stage #1: 5-bromo-2-methyl-1H-indole-3-carboxylic acid ethyl esterwith potassium hydroxide in N,N-dimethyl-formamide at 0; for 0.5 h;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 0;
References:
Sellitto, Grazia;Faruolo, Aurora;De Caprariis, Paolo;Altamura, Sergio;Paonessa, Giacomo;Ciliberto, Gennaro [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 16,p. 6143 - 6148] Location in patent:supporting information; experimental part
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