1H-Indole-3-carboxylic acid, 5-bromo-1,2-dimethyl-, ethyl ester synthesis

2synthesis methods

Product Name:1H-Indole-3-carboxylic acid, 5-bromo-1,2-dimethyl-, ethyl ester
CAS Number:1245933-91-8
Molecular formula:C13H14BrNO2
Molecular Weight:296.16

1245933-87-2 Synthesis

ethyl 5-bromo-2-methyl-1H-indole-3-carboxylate

1245933-87-2
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74-88-4
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1H-Indole-3-carboxylic acid, 5-bromo-1,2-dimethyl-, ethyl ester

1245933-91-8
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Yield:1245933-91-8 92%

Reaction Conditions:

Stage #1: 5-bromo-2-methyl-1H-indole-3-carboxylic acid ethyl esterwith potassium hydroxide in N,N-dimethyl-formamide at 0; for 0.5 h;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 0;

References:

Sellitto, Grazia;Faruolo, Aurora;De Caprariis, Paolo;Altamura, Sergio;Paonessa, Giacomo;Ciliberto, Gennaro [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 16,p. 6143 - 6148] Location in patent:supporting information; experimental part

66416-72-6 Synthesis

66416-72-6
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141-97-9 Synthesis

141-97-9
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1245933-91-8
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References