Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE synthesis

4synthesis methods
To stirred solution of 18-crown-6 (4.40 g, 16.65 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.55 mL, 3.75 mmol), KHMDS (8.0 mL, 4.00 mmol, 0.5 M in toluene) was added via syringe in a dropwise manner at -78 oC. Ethyl chloroacetate (0.35 mL, 3.30 mmol) was added to the flask after 15 min. The reaction flask was allowed to warm to room temperature and stir for 4 hr. After standard workup procedure, the crude product was then purified by flash column chromatography (2:1-1:1 hexanes:EtOAc, Rf = 0.25 in 2:1 hexanes:EtOAc) yielding Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (808 mg, 2.43 mmol, 73.4%) as a yellow syrup.
BIS(2 2 2-TRIFLUOROETHYL)METHYLPHOSPHON&

757-95-9
19 suppliers
$64.59/5g

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

124755-24-4
81 suppliers
$33.00/1g

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: n-BuLi, HMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C
2: aq. HCl

References:

Patois;Savignac;About-Jaudet;Collignon [Synthetic Communications,1991,vol. 21,# 22,p. 2391 - 2396]

FullText

Ethyl chloroformate

541-41-3
6 suppliers
$19.39/5g

BIS(2 2 2-TRIFLUOROETHYL)METHYLPHOSPHON&

757-95-9
19 suppliers
$64.59/5g

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

124755-24-4
81 suppliers
$33.00/1g

References
BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE

92466-70-1
44 suppliers
$17.10/1g

105-36-2 Synthesis
Ethyl bromoacetate

105-36-2
346 suppliers
$5.00/5 g

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

124755-24-4
81 suppliers
$33.00/1g

References
2,2,2-Trifluoroethanol

75-89-8
460 suppliers
$9.00/1g

Acetic acid, (dichlorophosphinyl)-, ethyl ester

36957-54-7
0 suppliers
inquiry

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

124755-24-4
81 suppliers
$33.00/1g

References

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Related Search:

ETHYL (4-IODOBENZOYL)ACETATE BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE