4-Piperidinone, 5-broMo-3,3-diMethyl-1-[(4-Methylphenyl)sulfonyl]- synthesis

3synthesis methods

Product Name:4-Piperidinone, 5-broMo-3,3-diMethyl-1-[(4-Methylphenyl)sulfonyl]-
CAS Number:1247885-06-8
Molecular formula:C14H18BrNO3S
Molecular Weight:360.27

1247885-05-7 Synthesis

4-Piperidinone, 3,3-diMethyl-1-[(4-Methylphenyl)sulfonyl]-

1247885-05-7
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4-Piperidinone, 5-broMo-3,3-diMethyl-1-[(4-Methylphenyl)sulfonyl]-

1247885-06-8
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Yield:1247885-06-8 100%

Reaction Conditions:

with phenyltrimethylammonium tribromide in tetrahydrofuran at 20; for 3 h;

Steps:

196.d

A solution of 3,3-dimethyl-l-tosylpiperidin-4-one (22.5 g, 80 mmol) in THF (400 mL), PTT (30 g, 80 mmol) was added in portions. The reaction mixture was stirred at RT for 3 h. The reaction mixture was filtered, and the filtrate was concentrated under vacuum to give the title compound as a yellow solid. (28.7 g, 100 %); LC/MS: m/e = 362 (M+H)⁺.

References:

WO2010/114971,2010,A1 Location in patent:Page/Page column 220

98-59-9 Synthesis

98-59-9
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1247885-06-8
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References

648921-37-3 Synthesis

648921-37-3
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References