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(S)-1-Isopropyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid synthesis

2synthesis methods
(S)-BENZYL 2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

103300-84-1
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(S)-1-Isopropyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid

124799-00-4
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 61.1 percent / PPh3, DEAD / dioxane / 4 h / Heating
2: 57.8 percent / hydrogen / 10percent Pd/C / ethanol / 3 h / Ambient temperature

References:

Suzuki;Maeda;Kondo;Sugano;Matsumoto [Chemical and Pharmaceutical Bulletin,1989,vol. 37,# 7,p. 1764 - 1769]