(2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester synthesis
- Product Name:(2S)-2-[(Ethylthio)carbonyl]-5-oxo-1-pyrrolidinecarboxylic Acid tert-Butyl Ester
- CAS Number:1298023-90-1
- Molecular formula:C12H19NO4S
- Molecular Weight:273.35
24424-99-5
825 suppliers
$13.50/25G
1298024-11-9
4 suppliers
$650.00/500mg
1298023-90-1
4 suppliers
$650.00/250mg
Yield:1298023-90-1 77%
Reaction Conditions:
with dmap in acetonitrile at 20; for 2 h;Cooling with ice;
Steps:
43.2 Step 2:
Preparation of tert-butyl (S)-2-((ethylthio)carbonyl)-5-oxopyrrolidine-1-carboxylate
S-Ethyl (S)-5-oxopyrrolidine-2-carbothioate (6 g, 34.6 mmol) was dissolved in MeCN (35 mL) in an ice bath, and then Boc2O (8.28 mL, 35.0 mmol) and DMAP (470 mg, 3.46 mmol) were added successively.
The reaction solution was warmed up to room temperature slowly, and stirred at this temperature for 2 hours.
The reaction solution was added with saturated aqueous NaHCO3 solution (20 mL), and extracted with ethyl acetate (100 mL * 2).
The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.
The residue was subjected to column chromatography to obtain the title compound S-ethyl (S)-5-oxopyrrolidine-2-carbothioate (7.3 g, 77%).
References:
EP3590931,2020,A1 Location in patent:Paragraph 0212-0213
53100-44-0
223 suppliers
$10.00/1g
75-08-1
218 suppliers
$16.19/25ml
1298023-90-1
4 suppliers
$650.00/250mg
98-79-3
599 suppliers
$5.00/25g
1298023-90-1
4 suppliers
$650.00/250mg