![](/CAS/20150408/GIF/1303609-36-0.gif)
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxaMide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-diMethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-1'-[(1R,2S)-2-hydroxy-1,2-diphenylethyl]-2-oxo-, (2'R,3S,4'S,5'R)- synthesis
- Product Name:Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxaMide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-diMethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-1'-[(1R,2S)-2-hydroxy-1,2-diphenylethyl]-2-oxo-, (2'R,3S,4'S,5'R)-
- CAS Number:1303609-36-0
- Molecular formula:C43H46Cl2FN3O4
- Molecular Weight:758.75
Yield:1303609-36-0 72%
Reaction Conditions:
in tetrahydrofuran at 20; for 48 h;
Steps:
12.3
The solution of compound 6 (965 mg, 1.5 mmol) and amine 7 (346 mg, 3 mmol) in 5 mL of THF was stirred at room temperature for 2 days and the solvent was removed under reduced pressure. The residue was purified by silica gel flash column chromatography (n-hexane/ethyl acetate=1:1 to 1:4) to give compound 8 (819 mg, 72% yield).
References:
US2011/112052,2011,A1 Location in patent:Page/Page column 152
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