2-(cyclopropylmethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 120 h / 20 °C / Inert atmosphere
2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.5 h / 110 °C / Microwave irradiation

References:

GLAXOSMITHKLINE LLC;AMANS, Dominique;BAMBOROUGH, Paul;BIT, Rino, Antonio;BROWN, John, Alexander;CAMPBELL, Matthew;LINDON, Matthew, John;SHIPLEY, Tracy, Jane;THEODOULOU, Natalie, Hope;WELLAWAY, Christopher, Roland;WESTAWAY, Susan, Marie WO2014/78257, 2014, A1