ChemicalBook CAS DataBase List Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate

Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate synthesis

11synthesis methods

Product Name:Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate
CAS Number:136285-69-3
Molecular formula:C23H21N3O2
Molecular Weight:371.43

21606-04-2 Synthesis

21606-04-2
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Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate

136285-69-3
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Yield:-

Steps:

Multi-step reaction with 7 steps
1: SOCl₂, DMF / toluene / 0.5 h / Heating
2: NaN₃ / acetone; H₂O / 1 h
3: 1.5 h / Heating
4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating
5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
7: 78 percent / ethanol / 1.5 h / Heating

References:

Kubo, Keiji;Kohara, Yasuhisa;Imamiya, Eiko;Sugiura, Yoshihiro;Inada, Yoshiyuki;et al. [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2182 - 2195]

141-52-6 Synthesis