ChemicalBook CAS DataBase List Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate synthesis

9synthesis methods

Product Name:Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate
CAS Number:139481-44-0
Molecular formula:C25H21N3O3
Molecular Weight:411.45

78-09-1 Synthesis

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Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

139481-44-0
320 suppliers
$9.00/5g

Yield:139481-44-0 86%

Reaction Conditions:

with acetic acid at 80; for 1 h;

Steps:

1

To a solution of compound 8 in tetraethyl orthocarbonate (5 mL), acetic acid (0.37 g) was added, and the mixture was stirred at 80 °C for 1 h, the reaction mixture was concentrated, and the residue was dissolved in ethyl acetate. Washed with water, evaporated to dryness, The crystal was recrystallized from ethyl acetate-hexane.Obtained 2.01g of colorless crystal,Yield 86%, compound 5.

References:

CN108658961,2018,A Location in patent:Paragraph 0011; 0062; 0064