(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester synthesis

4synthesis methods

Product Name:(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester
CAS Number:1373492-32-0
Molecular formula:C14H14ClNO3
Molecular Weight:279.7189

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(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

1373492-32-0
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Yield:-

Steps:

Multi-step reaction with 5 steps
1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Cooling in water bath
2: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere
3: pyridinium chlorochromate / dichloromethane / 1 h / Inert atmosphere
4: dichloromethane / 4 h / 20 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

References:

WO2012/54535,2012,A2

29270-30-2 Synthesis

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References

tert-Butyl 5-oxo-5,6-dihydropyridine-1(2H)-carboxylate

156496-89-8
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References

224779-27-5 Synthesis

N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE

224779-27-5
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References