ChemicalBook CAS DataBase List SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl- synthesis

6synthesis methods

Product Name:SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-
CAS Number:1393813-42-7
Molecular formula:C13H14BrClN4O2S
Molecular Weight:405.7

146533-41-7 Synthesis

5-(4-Bromophenyl)-4,6-dichloropyrimidine

146533-41-7
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SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl-

1393813-42-7
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Yield:1393813-42-7 115 g

Reaction Conditions:

with sodium hydroxide in dimethyl sulfoxide at 40; for 6 h;

Steps:

1 Preparation of sulfamide (III)

600 ml of DMSO was added to 6.4 g of Sodium hydroxide, 100 g of reacting 5-(4- bromophenyl)-4,6dichloropyrimidine, followed by 116 g of N-propyl sulfomyl amide potassium salt (Sodium salt can also be used). The reaction mixture was stirred at 40±5 °C for 6 hrs. On completion of the reaction, the reaction mass was cooled to 27±2 °C and 1000 ml of purified water was added. The pH was adjusted with IN HC1 solution, followed by filtration. Wet cake was further treated with purified water and heated at 50±2 °C for 30 minutes, cooled at 27±2 °C. The solid was filtered, washed with purified water. The water slurry wet material was further subjected to methanol purification, heated at 50±2 °C for 30 mins, cooled at 27±2 °C. The final solid obtained was washed with methanol and dried under vacuum at 43±2 °C for 12 hours.Dry weight: 115g

References:

WO2017/33016,2017,A1 Location in patent:Page/Page column 16

146533-41-7 Synthesis

146533-41-7
306 suppliers
$16.00/1g