4-Thiazolecarboxylic acid, 5-[(ethoxycarbonyl)amino]-, ethyl ester synthesis
- Product Name:4-Thiazolecarboxylic acid, 5-[(ethoxycarbonyl)amino]-, ethyl ester
- CAS Number:1394941-05-9
- Molecular formula:C9H12N2O4S
- Molecular Weight:244.27
2999-46-4
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$13.43/1gm:
16182-04-0
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1394941-05-9
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$65.00/50mg
Yield:1394941-05-9 92%
Reaction Conditions:
Stage #1: Ethyl isocyanoacetatewith potassium tert-butylate in tetrahydrofuran at -25; for 0.25 h;Inert atmosphere;
Stage #2: Ethoxycarbonyl isothiocyanate in tetrahydrofuran at -25 - 0; for 0.833333 h;Inert atmosphere;
References:
Shu, Lianhe;Alabanza, Lady Mae;Gu, Chen [Heterocycles,2012,vol. 85,# 7,p. 1721 - 1726] Location in patent:experimental part