ChemicalBook CAS DataBase List methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate

methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate synthesis

9synthesis methods

Product Name:methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate
CAS Number:1421312-36-8
Molecular formula:C20H18N2O5
Molecular Weight:366.37

methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

1421312-35-7
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5680-79-5 Synthesis

5680-79-5
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$3.66/25g

methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate

1421312-36-8
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Yield: 85.1%

Reaction Conditions:

with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;triethylamine in dichloromethane;water at 40;

Steps:

4; 1-7 Example 4 Preparation of Compound F (R is a methyl group)
Weigh 2.0 g of Compound D in a three-necked flask containing 20 ml of dichloromethane: water in 1:1 solution.2.5 g of EDCI, 1.8 g of HOBt, 1.3 g of triethylamine and 1.1 g of glycine methyl ester hydrochloride were successively added, and the mixture was heated at 40 ° C overnight.After the reaction is completed, the reaction solution is placed in a separatory funnel and extracted and purified. The upper layer of methylene chloride is separated and dried to give a yellow solid.Material F (yield 85.1%, purity 97.5%).The lower aqueous layer can continue to be used as a solvent for the preparation of compound F.

References:

Nanjing Zhengda Tianqing Pharmaceutical Co., Ltd.;Nanjing Baimai Biological Co., Ltd.;Zhu Yucheng;Zhao Mingli;Chai Yuzhu;Zhang Tianlong;Shi Xueyi;Wang Yuan CN109956901, 2019, A Location in patent:Paragraph 0067-0070; 0076-0082

1421312-34-6 Synthesis