N-(9,9-dimethyl-9H-fluoren-2-yl)dibenzo[b,d]furan-3-amine synthesis
- Product Name:N-(9,9-dimethyl-9H-fluoren-2-yl)dibenzo[b,d]furan-3-amine
- CAS Number:1427556-50-0
- Molecular formula:C27H21NO
- Molecular Weight:375.46
89827-45-2
200 suppliers
$7.00/1g
108714-73-4
306 suppliers
$6.00/1g
1427556-50-0
23 suppliers
inquiry
Yield: 83.4%
Reaction Conditions:
with 1,1'-bis(diphenylphosphino)ferrocene;palladium diacetate;sodium t-butanolate in toluene at 80; for 12 h;Inert atmosphere;
Steps:
Synthesis of Intermediates A6 to A9
Intermediates A6 to A9 can be prepared according to Scheme I above. The starting materials Ar 1 - NH 2 (arylamine) and Br - Ar 2 (aryl bromide) are listed in Table 2 below.Briefly, aryl bromide (1.0 eq), aryl amine (1.05 eq), Pd (OAc) 2 (0.01 eq), 1,1'-bis (diphenylphosphino) ferrocene (0.04 eq) , Sodium tert-butoxide (1.5 eq) and toluene was placed in a pressure tube and heated under N 2 atmosphere at 80 ° C. for 12 hours.After the reaction was complete, the volatiles were removed under vacuum and the resulting solution was extracted with dichloromethane (3 x 60 mL).The combined organic extracts were washed with brine (brine) solution, dried over Na2SO4 and concentrated to leave a yellow solid.In addition, the crude product was purified by silica gel column chromatography by using hexane / dichloromethane mixture (2: 1 v / v) as eluent.The analytical data of the products obtained, ie intermediates A 6 to A 9, are listed in Table 2 below.
References:
Nichem Fine Technology Co., Ltd.;Liao, Liang Di;Wu, Hui Ling;Shieh, Shwu Ju;Chen, Chi Chung JP6446099, 2018, B1 Location in patent:Paragraph 0057-0060
![3-Bromodibenzo[b,d]furan](/CAS/GIF/26608-06-0.gif)
26608-06-0
189 suppliers
$8.00/250mg
108714-73-4
306 suppliers
$6.00/1g
1427556-50-0
23 suppliers
inquiry