ChemicalBook CAS DataBase List 2-Amino-9,9-dimethylfluorene

2-Amino-9,9-dimethylfluorene synthesis

5synthesis methods

Product Name:2-Amino-9,9-dimethylfluorene
CAS Number:108714-73-4
Molecular formula:C15H15N
Molecular Weight:209.29

605644-46-0 Synthesis

605644-46-0
144 suppliers
$8.00/1g

108714-73-4
304 suppliers
$6.00/1g

Yield:108714-73-4 88%

Reaction Conditions:

with palladium on activated charcoal;hydrazine hydrate in ethanol for 4 h;Reflux;

Steps:

Preparation of 2-amino-9,9-dimethylfluorene (4):
10 g of 2-nitro-9,9-dimethylfluorene was added to the reaction flask, and stirred and dissolved with 80 m of ethanol.When 2-nitro-9,9-dimethylfluorene is completely dissolved into a clear solution,30 m L of hydrazine hydrate was added dropwise. After the addition was completed, 2 g of palladium on carbon catalyst was added, and then refluxed for 4 h. Finally, the color of the reaction liquid was very bright and dark red.Then directly hot filter,distillation under reduced pressure gave 7.7 g of a white solid, yield 88%, product content 99%.

References:

Liaoning Bo Mei Pharmaceutical Technology Co., Ltd.;Zhou Xiaoming;Pan Dalin;Jiang Chao;Li Wei;Wang Yan;Jiang Lin CN109824523, 2019, A Location in patent:Paragraph 0018

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28320-31-2 Synthesis