ChemicalBook CAS DataBase List (R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol

(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol synthesis

8synthesis methods

Product Name:(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol
CAS Number:1434652-66-0
Molecular formula:C14H20O4
Molecular Weight:252.31

1434652-62-6 Synthesis

2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol

1434652-62-6
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(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol

1434652-66-0
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Yield:1434652-66-0 52%

Reaction Conditions:

with Venusil Chiral OD-H in ethanol;hexane;

Steps:

76 Synthesis of Compound 76.2.

Synthesis of Compound 76.2. [0802] The enantiomers of 76.1 (22 g) were resolved by chiral preparative HPLC under the following conditions (Gilson Gx 281): Column: Venusil Chiral OD-H, 21.1*25 cm, 5 μm; mobile phase: hexanes (0.2% TEA) and ethanol (0.2% TEA) (hold at 10% ethanol (0.2% TEA) for 13 min); detector: UV 220/254 nm. 11.4 g (52%) of 76.2 were obtained as a white solid.

References:

US2013/123231,2013,A1 Location in patent:Paragraph 0798; 0801; 0802

2081-44-9 Synthesis