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4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLIC ACID synthesis

3synthesis methods
144061-14-3 Synthesis
ETHYL 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]THIAZOLE-5-CARBOXYLAT

144061-14-3
17 suppliers
$50.00/100mg

4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLIC ACID

144059-85-8
9 suppliers
$94.25/1g

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Yield:144059-85-8 86%

Reaction Conditions:

with sodium hydroxide in ethanol;water at 85; for 1.5 h;

References:

Sierra, Michael L.;Beneton, Véronique;Boullay, Anne-Bénédict;Boyer, Thierry;Brewster, Andrew G.;Donche, Frédéric;Forest, Marie-Claire;Fouchet, Marie-Hélène;Gellibert, Fran?oise J.;Grillot, Didier A.;Lambert, Millard H.;Laroze, Alain;Le Grumelec, Christelle;Linget, Jean Michel;Montana, Valerie G.;Nguyen, Van-Loc;Nicodème, Edwige;Patel, Vipul;Penfornis, Annie;Pineau, Olivier;Pohin, Danig;Potvain, Florent;Poulain, Géraldine;Ruault, Cécile Bertho;Saunders, Michael;Toum, Jér?me;Xu, H. Eric;Xu, Robert X.;Pianetti, Pascal M. [Journal of Medicinal Chemistry,2007,vol. 50,# 4,p. 685 - 695]