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144527-44-6

(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride synthesis

2synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
833 suppliers
$13.50/25G

40216-83-9 Synthesis
trans-4-Hydroxy-L-proline methyl ester hydrochloride

40216-83-9
316 suppliers
$6.00/5g

(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride

144527-44-6
16 suppliers
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Yield:144527-44-6 18.42 g

Reaction Conditions:

with triethylamine in acetonitrile at 0 - 20;

References:

Hack, Verena;Reuter, Cédric;Opitz, Robert;Schmieder, Peter;Beyermann, Michael;Neud?rfl, J?rg-Martin;Kühne, Ronald;Schmalz, Hans-Günther [Angewandte Chemie - International Edition,2013,vol. 52,# 36,p. 9539 - 9543][Angew. Chem.,2013,vol. 125,# 36,p. 9718 - 9722] Location in patent:supporting information