1H-Pyrrole-2-carboxylicacid,3-amino-4-cyano-1-methyl-,ethylester(9CI) synthesis
- Product Name:1H-Pyrrole-2-carboxylicacid,3-amino-4-cyano-1-methyl-,ethylester(9CI)
- CAS Number:145162-36-3
- Molecular formula:C9H11N3O2
- Molecular Weight:193.2
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Yield:145162-36-3 60%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60; for 6 h;
Steps:
4.1. General method for the synthesis of methyl-3-amino-4-cyano-1,5-dimetyhl-1H-pyrrole-2-carboxylate
General procedure: 2.25 g of sarcosine were added to a cold solution of 5 mL ofacetyl chloride and 22.5 mL of alcohol. The mixture was then heated under reflux for 3 h, leading to the formation of sarcosinechlorohydrate. In the second step, sodium carbonate (K2CO3)(10 mmol) was added to the mixture with ethoxymethylenemalononitrile(10 mmol) and dimethylformamide(DMF) (30 mL). The reaction was heated for 6 h at 60 °C. The mixture was then poured into 100 ml of water; the compound in the resulting precipitate was then filtered and recrystallized from ethanol.
References:
Agrebi, Asma;Allouche, Fatma;Alves, Sérgio;Baleiz?o, Carlos;Cherif, Oussama;Farinha, José Paulo [Journal of Molecular Structure,2020,vol. 1209]
![Propanedinitrile, [(methylamino)methylene]-](/CAS/GIF/79080-32-3.gif)
