Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate synthesis
- Product Name:Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate
- CAS Number:150767-02-5
- Molecular formula:C13H20N2O3
- Molecular Weight:252.31
150767-00-3
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150767-02-5
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Yield:150767-02-5 70%
Reaction Conditions:
with palladium 10% on activated carbon;sodium formate in ethanol;water;
Steps:
3.2.4. General Procedure for the Preparation of Derivatives 1c, 8c-14c
General procedure: The hydrazones 1b, 8b-14b were subjected to catalytic reduction with Pd/C 10% (0.2 equiv.) andHCOONa (1.8 equiv.) dissolved in a 5:1 mixture of ethanol/water (1 mL/mmol). The mixture was stirredfor 1.5 h at 60 °C and then cooled down to a temperature below 40 °C and stirred for 12 h [22]. At theend of the reaction, the solution was extracted with EtOAc, dried over MgSO4, and concentratedin vacuo. The residue was purified by column chromatography (cyclohexane/EtOAc, 8:2) in yields of 70% (1c); 70% (8c, 9c, 12c) and 65% (11c, 13c).
References:
Casanova, Bruna B.;Muniz, Mauro N.;De Oliveira, Thayse;De Oliveira, Luís Flavio;Machado, Michel M.;Fuentefria, Alexandre M.;Gosmann, Grace;Gnoatto, Simone C. B. [Molecules,2015,vol. 20,# 5,p. 9229 - 9241]
870-46-2
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150767-02-5
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![Hydrazinecarboxylic acid, 2-[(3-methoxyphenyl)methylene]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/402723-13-1.gif)
402723-13-1
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150767-02-5
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123-11-5
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150767-02-5
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24424-99-5
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$13.50/25G
150767-02-5
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