ChemicalBook CAS DataBase List tert-butyl 4-((2S,5R)-5-(benzyloxyamino)piperidine-2-carboxamido)piperidine-1-carboxylate 4-methylbenzenesulfonate

tert-butyl 4-((2S,5R)-5-(benzyloxyamino)piperidine-2-carboxamido)piperidine-1-carboxylate 4-methylbenzenesulfonate synthesis

9synthesis methods

Product Name:tert-butyl 4-((2S,5R)-5-(benzyloxyamino)piperidine-2-carboxamido)piperidine-1-carboxylate 4-methylbenzenesulfonate
CAS Number:1510832-19-5
Molecular formula:C23H36N4O4
Molecular Weight:432.56

(2S,5R)-benzyl 5-(benzyloxyamino)piperidine-2-carboxylate

1171080-44-6
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87120-72-7 Synthesis

87120-72-7
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tert-butyl 4-((2S,5R)-5-(benzyloxyamino)piperidine-2-carboxamido)piperidine-1-carboxylate 4-methylbenzenesulfonate

1510832-19-5
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Yield:1510832-19-5 88%

Reaction Conditions:

with aluminum (III) chloride in toluene at 50; for 3 h;Solvent;Reagent/catalyst;

Steps:

1-4; 6 Example 1: (R1 is benzyl)

Put 30ml of toluene into the reaction flask, 0.7g (5.3mmol) of anhydrous aluminum chloride, 7.0g (35mmol) of compound III, 5g (14.7mmol) of compound II, keep at 50 until the reaction is complete (about 3 hours), add 50% 2.0g sodium hydroxide aqueous solution, filtered, layered, the organic phase was decompressed to dryness, crystallized with petroleum ether, suction filtered, and the filter cake was rinsed and dried with petroleum ether to obtain compound I5.6g, yield: 88%,

References:

CN111606844,2020,A Location in patent:Paragraph 0030-0041; 0045-0047