ChemicalBook CAS DataBase List (S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one synthesis

2synthesis methods

Product Name:(S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
CAS Number:1523412-59-0
Molecular formula:C13H17F3N4O2
Molecular Weight:318.29

1260585-11-2 Synthesis

(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

1260585-11-2
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74572-04-6 Synthesis

74572-04-6
173 suppliers
$10.00/250mg

(S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

1523412-59-0
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Yield:1523412-59-0 70%

Reaction Conditions:

with triethylamine at 180; for 1.5 h;Microwave irradiation;

References:

Pasquier, Benoit;El-Ahmad, Youssef;Filoche-Rommé, Bruno;Dureuil, Christine;Fassy, Florence;Abecassis, Pierre-Yves;Mathieu, Magali;Bertrand, Thomas;Benard, Tsiala;Barrière, Cédric;El Batti, Samira;Letallec, Jean-Philippe;Sonnefraud, Véronique;Brollo, Maurice;Delbarre, Laurence;Loyau, Véronique;Pilorge, Fabienne;Bertin, Luc;Richepin, Patrick;Arigon, Jér?me;Labrosse, Jean-Robert;Clément, Jacques;Durand, Florence;Combet, Romain;Perraut, Pierre;Leroy, Vincent;Gay, Frédéric;Lefran?ois, Dominique;Bretin, Fran?ois;Marquette, Jean-Pierre;Michot, Nadine;Caron, Anne;Castell, Christelle;Schio, Laurent;McCort, Gary;Goulaouic, Hélène;Garcia-Echeverria, Carlos;Ronan, Baptiste [Journal of Medicinal Chemistry,2015,vol. 58,# 1,p. 376 - 400]

16075-42-6
217 suppliers
$8.00/1g

1523412-59-0
11 suppliers
inquiry

References