Spiro[2.5]octane-1-carboxylic acid, 6-cyclohexyl-, methyl ester synthesis
- Product Name:Spiro[2.5]octane-1-carboxylic acid, 6-cyclohexyl-, methyl ester
- CAS Number:1539278-01-7
- Molecular formula:C16H26O2
- Molecular Weight:250.38
![METHYL 2-([1,1-BI(CYCLOHEXAN)]-4-YLIDENE)ACETATE](/CAS/20180601/GIF/1539278-00-6.gif)
Yield:1539278-01-7 49%
Reaction Conditions:
Stage #1: methyl 2-(bi(cyclohexan)-4-ylidene)acetatewith sodium hydride in N,N-dimethyl-formamide;mineral oil; for 1.5 h;
Stage #2: trimethylsulfoxonium iodidewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 20; for 48 h;
References:
Brown, Dean G.;Bernstein, Peter R.;Griffin, Andrew;Wesolowski, Steve;Labrecque, Denis;Tremblay, Maxime C.;Sylvester, Mark;Mauger, Russell;Edwards, Phillip D.;Throner, Scott R.;Folmer, James J.;Cacciola, Joseph;Scott, Clay;Lazor, Lois A.;Pourashraf, Mehrnaz;Santhakumar, Vijayaratnam;Potts, William M.;Sydserff, Simon;Giguère, Pascall;Lévesque, Carine;Dasser, Mohammed;Groblewski, Thierry [Journal of Medicinal Chemistry,2014,vol. 57,# 3,p. 733 - 758]
92-68-2
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1539278-01-7
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