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ChemicalBook CAS DataBase List Methyl 1-Benzyl-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate

Methyl 1-Benzyl-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate synthesis

2synthesis methods
-

Yield:156779-10-1 53%

Reaction Conditions:

Stage #1: propynoic acid methyl ester;benzylamine in diethyl ether at -10 - 20; for 1 h;Inert atmosphere;
Stage #2: acryloyl chloride in tetrahydrofuran at 20; for 12 h;Inert atmosphere;

References:

O'Reilly, Elaine;Pes, Lara;Ortin, Yannick;Mueller-Bunz, Helge;Paradisi, Francesca [Amino Acids,2013,vol. 44,# 2,p. 511 - 518]