ChemicalBook CAS DataBase List TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE synthesis

3synthesis methods

Product Name:TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
CAS Number:158985-37-6
Molecular formula:C16H24N2O3
Molecular Weight:292.37

1-Boc-4-(4-methoxycarbonylphenyl)piperazine

158985-36-5
62 suppliers
$25.00/250mg

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

158985-37-6
58 suppliers
$42.00/250mg

Yield:158985-37-6 98%

Reaction Conditions:

Stage #1: 4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl esterwith diethylzinc;lithium chloride in tetrahydrofuran;hexane at 20; for 6 h;Inert atmosphere;
Stage #2: with sodium hydroxide in tetrahydrofuran;hexane;water at 20; for 8 h;Inert atmosphere;chemoselective reaction;

References:

Kovalenko, Oleksandr O.;Adolfsson, Hans [Chemistry - A European Journal,2015,vol. 21,# 7,p. 2785 - 2788] Location in patent:supporting information

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

162046-66-4
135 suppliers
$6.00/250mg

158985-37-6
58 suppliers
$42.00/250mg

References

197638-83-8
103 suppliers
$7.00/250mg

158985-37-6
58 suppliers
$42.00/250mg

References

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Sulfanilamide TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE